Endocrine Abstracts

Background: The incidence and prevalence of overt hypothyroidism have been reported to be 2 to 4/1,000 population/year and 8 to 13/1,000 population, respectively, in foreign countries. As there has been no nationwide survey to obtain data in Korea, the present study investigated the incidence and prevalence of overt hypothyroidism in Korea using claims data provided by the Health Insurance Review and Assessment Service. The proportions of causative diseases for hypothyroidism ...

Background: Selenium is an important trace element for thyroid hormone metabolism and its deficiency can cause hypothyroidism. Serum or plasma selenium concentration has been known as best biomarker which reflects selenium intake and reserve. We preliminarily assessed the serum or urine selenium concentrations in patients with thyroid disease compared to healthy normal population. We also investigated the correlation of serum selenium concentration with urine selenium concentr...

Background: Three deiodinase genes (DIO) play an important role in thyroid hormone metabolism. Among them, type 2 iodothyronine deiodinase (DIO2) converts T4 to T3 in brain and impaired psychological well-being was reported in minor variants of DIO2. However, the prevalence of three DIOs and their relation to neuropsychological status has not been evaluated in Asian hypothyroid subjects.Methods: We prospectively enrolled 196 subjects who were taking levo...

Background: Recent studies have shown associations of thyroid hormone levels with metabolic syndrome (MetS) among euthyroid individuals, though there have been some inconsistencies. We evaluated the relationships between thyroid hormones and MetS in euthyroid middle-aged subjects in a large cohort.Methods: Retrospective analysis of 13 496 euthyroid middle-aged subjects who participated in comprehensive health examinations was performed. Subjects were gro...

Introduction: Macrophages and lymphocytes are considered as major players in adipose tissue (AT) inflammation and liver steatosis, contributing to metabolic dysregulation during obesity. The costimulatory molecules B7.1 and B7.2 are important regulators of T-cell activation and inflammatory reactions, however, their contribution in obesity-related AT and liver low-grade inflammation is poorly characterized.Methods: Mice sufficient or deficient in B7.1 an...

Neural cells are isolated from forebrain of 14.5 days old mouse embryos. In selective conditions these cells cluster forming sphere-like structures – neurospheres (NSCs). NSCs are heterogeneous structures containing only 2–5% of stem cells and progenitors being reportedly capable to transdifferentiate. Initially, aim of this study is to establish optimal culture conditions prior to investigation of transdifferentiation capacity of transplanted NSCs in kidney and adre...

Background and methods: The HORIZON-PFT is a multinational, 3-year, randomized, double-blind, placebo-controlled trial evaluating the potential of once-yearly zoledronic acid (ZOL) 5 mg, infused over 15 minutes, to decrease risk of fracture in 7736 postmenopausal osteoporotic women 65–89 years of age.Results: Treatment with ZOL 5 mg resulted in significant relative risk reductions in morphometric vertebral fracture of 70% vs PBO (3.8% vs 12.8%; 95% ...

Objective: To evaluate computed tomography (CT) features for diagnosing metastatic cervical lymph nodes (LNs) in patients with differentiated thyroid cancer (DTC) and propose CT-based risk stratification system modified from the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) guidelines.Materials and Methods: A total of 463 LNs from 397 patients with DTC who underwent preoperative CT staging and US-guided fine needle aspiration of LNs were in...

Objective: To evaluate the effectiveness and safety of ultrasound-guided RFA for symptomatic distant metastasis of DTC.Methods: The medical records of 12 patients who underwent RFA for palliative treatment of 18 symptomatic distant metastases from thyroid cancer between January 2008 and December 2020 were analyzed. All patients were assessed for their degree of discomfort, and were evaluated periodically as outpatients, clinically, and by imaging and ser...

Intrathyroidal thymic carcinoma (ITTC) is a rare thyroid malignancy. Its histology resembles that of squamous cell carcinoma (SCC) of the thyroid. However, ITTC shows a much more favorable prognosis than SCC. We analyzed the backgrounds and clinicopathological features of 10 patients who treated with ITTC in our medical center. Five patients was male, and another five was female. The average tumor size was 4mm, and it ranged from maximum 68mm to minimum 13mm. In pre-operative ...